Callum Keith Rennie was born in England and raised in Alberta, Canada, where he started out in university radio and worked his way to the renowned Shaw Festival. Rennie then moved to Vancouver, British Columbia, where he immediately landed many television appearances before being cast in his first independent feature-film role, in director Mina Shum's Double Happiness. That performance garnered him a Best Supporting Actor Genie Nomination.
He continued to star in many Canadian films, including Curtis's Charm, Men With Guns and Bruce MacDonald's critically acclaimed Hardcore Logo. At the same time, he starred on several television series, including My Life as a Dog (for which he won a Best Actor Gemini Award), Twitch City and Due South.
Rennie went on to star in other feature films, including Christopher Nolan's Memento; David Cronenberg's eXistenZ; Lynne Stopkewich's Suspicious River; Picture Claire, his second feature film with filmmaker Bruce McDonald; and Last Night, directed by Don McKellar — a turn that earned Rennie a Best Supporting Actor Genie Award. He then starred in the critically acclaimed Flower & Garnet, and in Falling Angels, opposite Miranda Richardson. Both films were shown at the Toronto International Film Festival, as has virtually every Canadian feature film in which Rennie has starred.
Next he was seen in Daniel MacIvor's Wilby Wonderful; Stephen King's miniseries Kingdom Hospital, directed by Craig R. Baxley; and in David Goyer's Blade: Trinity. Rennie worked opposite Jon Voight in the miniseries Five People You Meet in Heaven, appeared in Harry Hooks's Whiskey Echo, and starred with Ving Rhames and Freddie Prinze Jr. in Keoni Waxman's Shooting Gallery.
Rennie has appeared in Silk, starring Keira Knightley; in the Infinity Pictures project Butterfly on a Wheel, with Pierce Brosnan; in the New Line feature The Cleaner, opposite Cedric the Entertainer, Lucy Liu and Nicollette Sheridan; in David Goyer's The Invisible, opposite Marcia Gay Harden, for Touchstone and Spyglass Entertainment; and, finally, in the Paramount Pictures thriller Case 39, with Renee Zellweger.
His television credits continue to grow, with recent turns on the Syfy miniseries Tin Man, which now stands as the most-watched program to ever air on the network, and on such series as Painkiller Jane, The L Word, Supernatural and Smallville.