Neil Grayston began acting in high school in Port Moody, British Columbia. After graduation, he began his professional career by guest-starring on numerous Vancouver-shot television series, including the critically acclaimed teen series Edgemont Road.

Grayston played a recurring role as Alec, "the mouth-breather", on Fox's critically acclaimed dramedy Wonderfalls. He was nominated for a Leo Award (Canada) for his role as Martin, the stoic sous-chef, in the award-winning comedy series Godiva's. His guest-starring credits include turns on Smallville, The Dead Zone and Supernatural.

He currently resides in New Westminster, British Columbia, with his girlfriend and several fish.