Allison wants to hire Zane Donovan, a brilliant young particle physicist, to help Stark and Henry research the universe's earliest moments using a Chaotic Inflation Device that can, essentially, re-create the Big Bang. Zane, however, has just been arrested for stealing 3.1 million dollars from the government. As a result, Allison orders Jack to keep Zane in custody until he proves that he can be trusted.
Jack locks up Zane and, at Lupo's suggestion, fits him with a high-tech tracking bracelet that can also deliver mild electrical shocks and activate a restraining field if the prisoner tries to escape. In response, Zane cheerfully makes mischief. He grosses Jack out about Vincent's grilled chicken, flirts with Lupo and hacks the sheriff's office computer from within his jail cell. He pauses in his antics only when, on a trip to Global Dynamics, he's awed by the Chaotic Inflation Device.
On schedule, Stark and Henry activate the device, which will take 24 hours to build up to the Big Bang. That massive explosion must be contained by layered particle fields, which Henry must monitor closely. The next morning, however, Jack finds Henry laughing at cartoons while the protective fields weaken. Allison and Stark are also goofing off. In fact, Jack discovers that most people at Global are acting like kids - and pretty wacky kids at that.
Only a few scientists still have brainpower, and none of them knows how to fix the collapsing containment fields. One, a veterinarian named Dr. Emily Glenn, determines that the affected scientists have critically low levels of G.A.B.A. - gamma-aminobutyric acid. Loss of this neurotransmitter can cause Alzheimer's-like symptoms. Because specific types of radiation can diminish G.A.B.A., Jack wonders if Zane tweaked the Big Bang experiment to emit such radiation. Unfortunately, he can't ask, because Zane has just used his technical brilliance to ditch the tracking bracelet and break out of jail.
Zane's genius, however, is no match for Jack's common-sense police work. Soon back in custody, Zane swears that he would never sabotage the Chaotic Inflation Device, because it's too important an experiment. Choosing to believe him, Jack urges Zane to act generously and save the day. Zane agrees, but with only 43 minutes until the artificial Big Bang occurs, there may not be time for him to fix the containment fields. Meanwhile, Dr. Glenn proves that radiation isn't causing the scientists' mental decline. Even if Zane succeeds, Jack must still discover what's causing Eureka's epidemic of silliness.
Wormholes start popping up all over, threatening to rip Eureka apart unless Carter can stop them.