At times, earthbound ghosts cling to the living because they have unfinished business in our world that prevents them from "crossing over". They need help completing their transition and Melinda Gordon (Jennifer Love Hewitt) has the gift to do it.

Inspired in part by the work of famed medium James Van Praagh and of Mary Ann Winkowski, a real-life communicator with earth bound spirits, Ghost Whisperer explores the spiritual side of life and death. Melinda navigates between the dead and the living with her chilling, heart-rending and sometimes amusing actions as an intermediary between the ghosts and those they haunt. And although she's great being a mediator, she never publicizes her gift. Instead she's primarily known around town as a newlywed and owner of the successful antiques store, Same As it Never Was.

In addition to Melinda's husband, firefighter Jim Clancy (David Conrad), only a few close friends know her secret. For her part, Melinda accepts her unique abilities as a blessing and sometimes a curse, but always helps her clients, alive or dead, find emotional closure.