The veteran actor played Dr. Franklin Storm in the 2015 reboot of Fantastic Four. He was also popular in genre circles as Chief Byron Giles in the horror series Outcast.
Beyond genre pieces, Cathey was well-known for playing Freddy on the Netflix show House of Cards, which earned him three consecutive Emmy Award nominations for Outstanding Guest Actor in a Drama Series, including a win in 2015.
He also appeared in The Wire, whose creator, David Simon, first reported Cathey's death on Twitter with a tribute that read: "Reg Cathey, 1958-2018. Not only a fine, masterful actor -- but simply one of the most delightful human beings with whom I ever shared some long days on set. On wit alone, he could double any man over and leave him thinking. Reg, your memory is a great blessing."
One of the actor's early roles was on Star Trek: The Next Generation in 1993, playing Commander Morag, an officer in the Klingon Defense Force during the late 24th century. Following that, Cathey starred as Freeze in The Mask (1994) the main antagonist's friend and bodyguard who gets killed by Jim Carrey's titular character.
Other notable parts included playing The Baron in fantasy series Grimm, Deetee in Tank Girl (1995), and prison warden Martin Querns in HBO's Oz from 2000-2003. He also provided voice work for the video game Star Wars: The Old Republic - Rise of the Hutt Cartel. Further movie credits included: Born on the Fourth of July (1989), What About Bob? (1991), Clear and Present Danger (1994), Seven (1995), American Psycho (2000) and Pootie Tang (2001).
The Emmy-winning actor was born in Huntsville, Alabama. After spending some of his childhood in West Germany, Cathey later studied theatre at the University of Michigan and the Yale School of Drama, according to The Detroit Free Press.
Other stars lead tributes to Cathey on Friday, including Ant-Man star Bobby Cannavale who tweeted: "We lost a sweet, sweet man and a sweet, sweet, SWEET artist today. Rest In Power, Reg E. Cathey We will miss you."
Luke Cage star Mike Colter also paid his respects, tweeting: "Go gentle into that good night my brother. It was an honor spending time with you on set. Getting to know you as a person and an artist. You will be missed. Condolences to your family. I salute you. #Reg E. Cathey."
What are some of your favourite performances by Reg E. Cathey? Let us know in the comments below.