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Credit: 20th Century Fox

Deadpool 2 set to dethrone Avengers: Infinity War at box office this weekend

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May 16, 2018, 12:13 PM EDT

Could the Merc With a Mouth end up dethroning Thanos & Co. as king of the weekend box office? Well, a report from Deadline suggests it's certainly possible. 

Analysts believe that 20th Century Fox’s Deadpool 2, which opens this Friday, is set to make as much as $350 million globally this weekend. Broken down, that’s between $130 million and $150 million domestically and $175 million to $200 million overseas. 

Now, this doesn’t come close to breaking Avengers: Infinity War’s record-breaking global opening weekend box office grab of nearly $641 million. Heck, as impressive as this opening will be, let’s face it: not even Deadpool can defeat Earth’s Mightiest Heroes. But this does mean the Deadpool sequel is presumed to replace Infinity War as the #1 box officer winner for the weekend beginning May 19. Infinity War has been the #1 movie at the box office winner for three consecutive weekends, according to Box Office Mojo.  

If Deadpool 2 opens at the higher end of its predicted range, it would beat the record reached by the previous Deadpool film for the biggest opening weekend for an R-rated film. The original Deadpool wound up being a surprise hit, opening with $132.4 million domestically in 2016. It later earned $783 million total worldwide, making it the highest-grossing R-rated movie ever, Variety noted.  

Deadpool 2 stars Ryan Reynolds as the titular wisecracking anti-hero and Josh Brolin as the mutant Cable. It’s written by Rhett Reese, Paul Wernick, and Reynolds, and directed by David Leitch (John Wick). It opens in theatres May 18. 

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