After a series of nuclear blasts rocked the country, the gang tracked down Murphy to Cheyenne, Wyoming, where he had set up shop at a zombie strip club.
The man responsible for those deaths? Hector Alvarez, aka Escorpion, the head enforcer of a criminal empire known as the Zeros. The gang has to contend with them … and with the scores of bounty hunters who are after 'The Murphy.'
The team encountered quite a few characters en route to the CDC in California. Characters like Sam Custer (William Sadler), a trucker leading a convoy of survivors to Edmonton, Canada (it doesn't end well) …
Bernadette (Missi Pyle), the kooky leader of a group of 'extranauts' who believe they'll soon be rescued from the apocalypse by a race of aliens … and that Murphy is their emissary ...
… and Dr. Gideon Gould (Anthony Michael Hall), a world-renowned expert in conflict resolution who's spending the apocalypse with a group of survivors at a never-ending corporate retreat.
The gang was also reunited with some old pals from Season 1 … like Sketchy and Skeezy, con men from the Fu-Bar whose latest shenanigans get them in trouble with the Zeros …
After flirting with paternal instincts for a little while, Murphy ultimately gives Lucy to a kindly couple to raise as their own (not that they have a choice, as Murphy gives them the magic bite that makes anyone do his bidding).
At the U.S.-Mexico border, the team meets La Reina (Gina Gershon), the reigning Queen of the Zeros cartel. La Reina plans to cultivate the cure from Murphy's blood and distribute it to the world herself, with a little help from …
… Dr. Kurian, the man responsible for the Z virus in the first place. However, he plans to use the vaccine to create an army under Murphy's control, which of course goes extremely well.
After escaping from the Zeros compound, the gang actually makes it to the CDC, which is now based out of a small restaurant run by a lady known as Auntie …
… Murphy, refusing to be a "blood bag for rich people," has escaped from the submarine with Dr. Merch (remember her?) and the captain in tow, with a wounded 10K nowhere in sight …
… and Roberta, Doc and Addy have teamed up with Hector, who has changed apparently changed his ways after receiving a mighty beating from Vasquez, and his sweet ride.
When we last see Citizen Z, he and his trusty canine have abandoned the Northern Light listening station and are now traversing the snowy wasteland, where a MYSTERY FIGURE approaches them! Who could it be ...?