Keith Allan plays Murphy, the only known survivor of a zombie bite (well, multiple zombie bites).
Tom Everett Scott (yes, that Tom Everett Scott) plays Charles Garnett, ex-National Guard and all around asskicker.
Garnett's asskicking is perhaps only eclipsed by Roberta Warren, played by Kellita Smith.
Mark Hammond - played by Harold Perrineau - is trying to get Murphy across the country to a protected military base that can use his blood to find a cure for the zombie virus that's destroyed the world.
Okay, spoiler alert about Z Nation: There's a lot of characters that kill lots of zombies, as Hammond is prepping to do here.
Have guns, will travel.
Helping the characters in their quest to transport Murphy is Citizen Z, an NSA agent at a remote listening post in the arctic.
Citizen Z is played by DJ Qualls. Yes, the dude from Road Trip!
Recognize Kellita? She's a film and TV veteran, most known for her role on The Bernie Mac Show.
Russell Hodgkinson plays Doc, an ex-addict who is not actually a doctor. He's just experimented a lot and has a REALLY strong stomach.
Michael Welch plays Mack, all-american golden boy and boyfriend to....
....Addy, a seemingly-timid-but-in-truth-a-butt-kicker played by Anastasia Baranova.
Pisay Pao plays Cassandra, one of the survivors.
Little is known about Cassandra's past, but none of it is a happy one.
Nat Zang plays 10K, of whom little is known - except he plans on killing 10,000 zombies (he's not there yet, but Season 1 is 13 episodes so stay tuned).
Also. Zombies! This show is overflowing with zombies!