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As Citizen Z tries to undo any of the damage that's been done by the hacking, he also tries to reach Operation Bitemark to tell them they're compromised and to abort the mission. Unfortunately, he's too late, as the team has already arrived at the coordinates they were given for the CDC ... which is actually a quaint little restaurant in the middle of nowhere.
The team chats with Auntie, the owner and proprietor, who also happens to be the person to see if you're seeking the bounty on Murphy. As the team settles in, a group of bounty hunters turn up with a fake Murphy. Things quickly descend into a gunfight, and while all of the bounty hunters are killed, 10K is shot in the stomach!
Auntie contacts the CDC, which turns out to be based on a submarine. Military types -- and Dr. Merch! -- arrive, promising they'll help 10K as they take Murphy off to make a proper vaccine. The team says a pretty touching goodbye to Murphy, and the mission seems to be over ...
... that is, until the CDC departs and someone ELSE fires at the team. Yep, it's the Zeros, led by a now completely crazed La Reina. Luckily, Auntie's got some spare weapons and ammo hidden behind the bar.
On the submarine, Murphy learns that the crew belongs to a society currently living on a zombie-free island called Zona. Remember that? The place theorized by that lunatic in RoZwell? It's real!
Murphy notices that everyone on the sub has weird glowing eyes, a side effect of the current vaccine, which only slows down the effects the virus. Murphy is about to go along with tests for the new vaccine but suddenly incapacitates Dr. Merch, claiming he's going to do something he should have done "a long time ago."
Meanwhile, there's a big shootout at Auntie's restaurant, during which Auntie turns Z and Doc gives her mercy. Roberta and La Reina fight like crazy until finally La Reina is vanquished by … Hector, aka Escorpion!
Hector apologizes to Vasquez for murdering his family, saying he can have his vengeance if he wants it. Vasquez spares Hector's life, after which he says goodbye to Roberta and runs off into the woods, Rambo-style.
Roberta, Doc and Addy take Hector up on his offer: join him on the road, as he's got enough food, water, ammo and Z-Weed to last a month. "Worst case scenario, we kill him and take the truck," muses Addy. At the ocean, they see that Murphy has escaped the submarine and is now racing toward the shore on a speedboat ... with Dr. Merch and the Captain, who both have Murphy bite marks.
But where is 10K? If he's not on Murphy’s boat, then he's been blown up in the submarine .. which looks like a very likely scenario. 10K!!!
The Season 2 finale ends with the team being ambushed by a mystery foreign army, Citizen Z coming across a mystery figure as he traverses the frozen wasteland of the North Pole ... and young Lucy (Murphy's daughter!) enjoying a meal with her decomposing foster parents. On to Season 3!