Accidentally frozen, pizza-deliverer Fry wakes up 1,000 years in the future. He is taken in by his sole descendant, an elderly and addled scientist who owns a small cargo delivery service. Among the other crew members are Capt. Leela, accountant Hermes, intern Amy, obnoxious robot Bender and lobsterlike moocher "Dr." Zoidberg.
Hermes’ and the Professor’s sons try to outdo them in the business world but need their dads’ help when success overwhelms them; Bender becomes a brewmiester.
When the Earth is jeopardized by global warming, the crew attends a conference in Kyoto hosted by Al Gore’s head, and when the Earth’s increased temperature is linked to emissions from robots, Richard Nixon’s head attempts to rid the planet of them—including Bender.
The Planet Express crew finds itself pitted against the cast of the original Star Trek when an energy creature seeks to determine who is more worthy of his fanatical devotion.
Bender learns to cook and competes against the pretentious, popular chef Elzar in an Iron Cook chef contest; Dr. Zoidberg is struck with remorse when he frames Fry for his own misdeed.
When the Professor fine tunes his What-If Machine, Bender discovers what it would be like if he were human, Fry discovers what it would be like if life were more like a video game, and Leela discovers what it would be like if she found her true home.
While creating a team of mutants to play the Harlem Globetrotters, the Professor accidentally causes a disruption in time that threatens the existence of the universe, but may give Fry a chance to finally win Leela’s heart.
Fry and Bender become inadvertent participants in a bank robbery and are sentenced to a robot insane asylum where Fry comes to believe that he is indeed a robot.
Tired of feeling like an outcast, Leela has a second eye grafted onto her face; Bender adopts twelve children afterlearning about the government’s seemingly lucrative stipend.
