Eddie McClintock's break came with a role on the Fox comedy, Ned & Stacey. Fox soon became home for McClintock with his first starring role on the network's series Holding the Baby. He then starred in two series for NBC, Stark Raving Mad and AUSA. Other memorable television appearances include a role on the one-hour season finale of Friends, a recurring role on the WB's Felicity and guest-starring turns on such popular series as House M.D., Less Than Perfect, King of Queens, Sex in the City, Just Shoot Me, and Spin City. In 2006, McClintock starred with Jane Curtin, Fred Savage and William Devane in the ABC comedy Crumbs.
McClintock starred opposite Judd Hirsh, Nicholas Turturro and Jodi Lynn O'Keefe in the USA television movie Three Wise Guys and opposite Shannon Elizabeth in the Lifetime movie Confessions of an American Bride. He has also starred in several feature films, including Steven Soderbergh' s Full Frontal, director Roger Kumble's The Sweetest Thing, and the independent films Screenland Drive and Moving August.