Accidentally frozen, pizza-deliverer Fry wakes up 1,000 years in the future. He is taken in by his sole descendant, an elderly and addled scientist who owns a small cargo delivery service. Among the other crew members are Capt. Leela, accountant Hermes, intern Amy, obnoxious robot Bender and lobsterlike moocher "Dr." Zoidberg.
A tentacle creature from the Universe beyond the anomaly takes over our Universe; Leela, Amy, and Zap become the only resistance; and Bender becomes disillusioned with the League of Robots.
Zap leads a military strike on the anomaly; a heartbroken Fry decides to leave the Universe; and Bender's obsession with the League of Robots bears fruit.
Bender helps the aliens plunder history for its treasures; Lars and Leela's romance takes off; and a heartbroken Fry returns to the year 2000, pursued by a homicidal Bender.
Hermes loses his head; Leela falls in love; the Earth is taken over by email-scamming aliens; and the key to time travel is found in a tattoo of Bender on Fry's butt.
Nibbler enlists Fry in a mission to blow up evil brains bent on destroying the universe; Fry time travels into the past to prevent himself from being cryogenically frozen.
The Planet Express crew is exposed to a substance that causes everyone to revert to teenagers…and the Professor’s attempt to correct the problem only makes things worse.
A cryogenically frozen 1980’s guy is thawed, becomes the CEO of the failing Planet Express company, and threatens to have it acquired and gutted by it’s largest competitor.
In celebration of Freedom Day, Dr. Zoidberg eats the Earth flag, for which he is sentenced to death. In retaliation, the Decapodians enslave the entire world.